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In this model, knockout of the GLP1R in endothelial cells extinguished the beneficial effects of liraglutide, as shown by diminished ejection fraction and larger infarct size compared to mice with intact GLP1R expression [44]

GLP-1 stands for Glucagon-Like Peptide-1, which is a hormone that stimulates insulin production and reduces appetite

Meaningful changes in testosterone and estradiol could potentially be observed within the first few months of a study as body composition begins to change significantly

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But ultimately, they need to be studied more